Abstract #0199
Towards Early Detection of Pancreatic Cancers by CA19-9 Conjugated Magnetic Nanoparticles and Active Feedback MR
Zhao Li 1 , Chaohsiung Hsu 1 , Vay Liang W. Go 2 , and Yung-Ya Lin 1
1
Chemistry and Biochemistry, UCLA, Los
Angeles, CA, United States,
2
UCLA
Center for Excellence in Pancreatic Diseases, UCLA, Los
Angeles, CA, United States
Early detection of pancreatic cancers using enhanced MRI
techniques increases not only the treatment options
available, but also the patients survival rate. This
can be achieved with antibody-conjugated
superparamagnetic iron oxide (SPIO) nanoparticles
capable of binding to early stage pancreatic cancer
cells to improve imaging specificity and innovation
methods that can sensitively detect SPIO to improve
imaging sensitivity. The enhanced contrast from SPIO can
then be used to visually assess the distribution and
magnitude of SPIO-targeted tumor cells. In vivo
subcutaneous and orthotopic xenografts mouse models
validated the superior contrast/sensitivity and
robustness of this approach towards early pancreatic
cancers detection.
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