PARASHIFT contrast agents - a new approach for molecular imaging by MRI
Ian Wilson 1 , Peter Harvey 2 , Katie-Lousie Finney 2 , Alexander M Funk 2 , P Kanthi Senanayake 2 , Ross J Maxwell 1 , David Parker 2 , and Andrew M Blamire 3
Northern Institute for Cancer Research,
Newcastle University, Newcastle upon Tyne, United
of Chemistry, Durham University, Durham, United Kingdom,
of Cellular Medicine, Newcastle University, Newcastle
upon Tyne, United Kingdom
A new class of contrast agents are demonstrated which
present new opportunities for molecular imaging by MRI.
By placing a tert-Butyl reporter group at a controlled
distance from a lanthanide ion, the dipolar interaction
gives rise to a frequency shifted reporter resonance
with short T1 which can be
vivo without contamination from endogenous water or fat
signal and with good sensitivity. These agents are
denoted PARASHIFT agents. An example of in vivo
detection of a dysprosium based agent is presented.
Comparison of in vivo spectral peak areas against a
reference standard suggested that a tissue concentration
of 1 micromolar was detectable in a scan duration of
only ~3 mins.
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