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Abstract #0200

PARASHIFT contrast agents - a new approach for molecular imaging by MRI

Ian Wilson 1 , Peter Harvey 2 , Katie-Lousie Finney 2 , Alexander M Funk 2 , P Kanthi Senanayake 2 , Ross J Maxwell 1 , David Parker 2 , and Andrew M Blamire 3

1 Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom, 2 Dept of Chemistry, Durham University, Durham, United Kingdom, 3 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

A new class of contrast agents are demonstrated which present new opportunities for molecular imaging by MRI. By placing a tert-Butyl reporter group at a controlled distance from a lanthanide ion, the dipolar interaction gives rise to a frequency shifted reporter resonance with short T1 which can be directly detected in vivo without contamination from endogenous water or fat signal and with good sensitivity. These agents are denoted PARASHIFT agents. An example of in vivo detection of a dysprosium based agent is presented. Comparison of in vivo spectral peak areas against a reference standard suggested that a tissue concentration of 1 micromolar was detectable in a scan duration of only ~3 mins.

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