Abstract #0202
Quantitative Magnetization Transfer Imaging of Human Sciatic Nerve at 3 Tesla
Richard D. Dortch 1,2 , Lindsey M. Dethrage 2 , Ke Li 1,2 , Bruce M. Damon 1,2 , John C. Gore 1,2 , and Seth A. Smith 1,2
1
Radiology and Radiological Sciences,
Vanderbilt University, Nashville, TN, United States,
2
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States
Previous work has demonstrated that the
macromolecular-to-free proton pool size ratio (
PSR
)
is related to myelin content; yet, no studies have
reported
PSR
mapping
in peripheral nerves
in
vivo
. This can be attributed to the challenges of
quantitative magnetization transfer (qMT) imaging in
nerve, including the influence of fat and the need for
higher resolution. The goal of this work was to develop
qMT approaches for the currently inaccessible (via
electrophysiology) sciatic nerves of healthy controls as
a baseline for future studies in neuropathy patients.
Our findings demonstrate that
PSR
can
be robustly measured in the sciatic nerve
in
vivo
.
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