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Abstract #0203

Reproducibility of in vivo inner and outer cortical magnetisation transfer ratio measurements

Rebecca Sara Samson 1 , Manuel Jorge Cardoso 2,3 , Nils Muhlert 1 , Varun Sethi 1 , Maria A Ron 1 , Sebastian Ourselin 2,3 , David H Miller 1 , Declan T Chard 1 , and Claudia A M Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 2 Centre for Medical Image Computing, UCL Department of Computer Sciences, UCL, London, United Kingdom, 3 Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom

A previous study suggests that outer cortical magnetization transfer ratio (MTR) has the potential to be a sensitive measure of pathology that is linked to clinical disease progression in relapse-onset multiple sclerosis. However, to determine the utility of the inner and outer cortical MTR measurement method it is important to determine the reproducibility of the technique. Here we demonstrate that inner and outer cortical MTR have coefficients of variation of 1.23% and 0.99% respectively.

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