Abstract #0203
Reproducibility of in vivo inner and outer cortical magnetisation transfer ratio measurements
Rebecca Sara Samson 1 , Manuel Jorge Cardoso 2,3 , Nils Muhlert 1 , Varun Sethi 1 , Maria A Ron 1 , Sebastian Ourselin 2,3 , David H Miller 1 , Declan T Chard 1 , and Claudia A M Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, United Kingdom,
2
Centre
for Medical Image Computing, UCL Department of Computer
Sciences, UCL, London, United Kingdom,
3
Dementia
Research Centre, Department of Neurodegenerative
Diseases, UCL Institute of Neurology, London, United
Kingdom
A previous study suggests that outer cortical
magnetization transfer ratio (MTR) has the potential to
be a sensitive measure of pathology that is linked to
clinical disease progression in relapse-onset multiple
sclerosis. However, to determine the utility of the
inner and outer cortical MTR measurement method it is
important to determine the reproducibility of the
technique. Here we demonstrate that inner and outer
cortical MTR have coefficients of variation of 1.23% and
0.99% respectively.
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