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Abstract #0211

In-vivo quantitative magnetization transfer imaging of de- and re-myelination in cuprizone-treated mice and correlation with histology

Laura Turati 1 , Fulvio Baggi 1 , Marco Moscatelli 1 , Alfonso Mastropietro 2,3 , Ileana Zucca 2 , Alessandra Erbetta 4 , Chiara Cordiglieri 1 , Greta Brenna 1 , Nicholas Dowell 5 , Renato Mantegazza 1 , Ludovico Minati 2,5 , and Mara Cercignani 5,6

1 Neuroimmunology and Neuromuscular Diseases Unit, Neurological Institute "Carlo Besta", Milan, Italy, 2 Scientific Department, Neurological Institute "Carlo Besta", Milan, Italy, 3 Department of Electronic, Information and Bioengineering, Politecnico of Milan, Milan, Italy, 4 Neuroradiology Unit, Neurological Institute "Carlo Besta", Milan, Italy, 5 CISC, Brighton and Sussex Medical School, Falmer, East Sussex, United Kingdom, 6 Neuroimaging Laboratory, IRCCS Santa Lucia, Rome, Italy

This paper presents a validation of the macromolecular pool ratio (F) derived from quantitative magnetization transfer (MT) imaging as myelin marker. In contrast with previous work in this area, which focused on ex-vivo validation, we used a reversible model of demyelination, namely cuprizone-treated mice, to investigate changes in F in the corpus callosum during demyelination and remyelination in vivo. A strong linear relationship was found between F and histological markers of myelin, providing the first direct confirmation that F estimated from quantitative MT imaging performed in-vivo is a viable proxy of myelin.

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