Abstract #0211
In-vivo quantitative magnetization transfer imaging of de- and re-myelination in cuprizone-treated mice and correlation with histology
Laura Turati 1 , Fulvio Baggi 1 , Marco Moscatelli 1 , Alfonso Mastropietro 2,3 , Ileana Zucca 2 , Alessandra Erbetta 4 , Chiara Cordiglieri 1 , Greta Brenna 1 , Nicholas Dowell 5 , Renato Mantegazza 1 , Ludovico Minati 2,5 , and Mara Cercignani 5,6
1
Neuroimmunology and Neuromuscular Diseases
Unit, Neurological Institute "Carlo Besta", Milan,
Italy,
2
Scientific
Department, Neurological Institute "Carlo Besta", Milan,
Italy,
3
Department
of Electronic, Information and Bioengineering,
Politecnico of Milan, Milan, Italy,
4
Neuroradiology
Unit, Neurological Institute "Carlo Besta", Milan,
Italy,
5
CISC,
Brighton and Sussex Medical School, Falmer, East Sussex,
United Kingdom,
6
Neuroimaging
Laboratory, IRCCS Santa Lucia, Rome, Italy
This paper presents a validation of the macromolecular
pool ratio (F) derived from quantitative magnetization
transfer (MT) imaging as myelin marker. In contrast with
previous work in this area, which focused on ex-vivo
validation, we used a reversible model of demyelination,
namely cuprizone-treated mice, to investigate changes in
F in the corpus callosum during demyelination and
remyelination in vivo. A strong linear relationship was
found between F and histological markers of myelin,
providing the first direct confirmation that F estimated
from quantitative MT imaging performed in-vivo is a
viable proxy of myelin.
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