Abstract #0212
Cerebral Blood Flow using pCASL MRI and Phase Contrast Angiography in a Large Cohort
Sudipto Dolui 1 , Raghav Mattay 2 , Ze Wang 3 , Mack Finkel 4 , Alex Smith 2 , Mark Elliott 2 , Lisa Desiderio 2 , Ben Inglis 5 , Bryon Mueller 6 , Danny J.J. Wang 7 , Lenore J. Launer 8 , Robert Kramer 8 , R. Nick Bryan 2 , and John A. Detre 9
1
Department of Neurology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Department
of Radiology, University of Pennsylvania, Philadelphia,
Pennsylvania, United States,
3
Department
of Psychiatry, University of Pennsylvania, Philadelphia,
Pennsylvania, United States,
4
Germantown
Friends School, Philadelphia, Pennsylvania, United
States,
5
Department
of Neuroscience, University of California, Berkeley,
California, United States,
6
Department
of Psychiatry, University of Minnesota, Minneapolis,
Minnesota, United States,
7
Department
of Neurology, University of California, Los Angeles,
California, United States,
8
Laboratory
of Epidemiology, Demography, and Biometry, National
Institute on Aging, Bethesda, Maryland, United States,
9
Departments
of Neurology and Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States
We compared whole brain cerebral blood flow (CBF)
measurements obtained using pCASL MRI and phase contrast
angiography (PCA) measurements in a large cohort of 544
subjects from the CARDIA study. CBF values showed highly
significant correlations throughout the velocity range,
providing no suggestion that pCASL labeling efficiency
drops at higher mean arterial velocities. There was also
considerable individual variability between CBF measured
by pCASL versus PCA, suggesting that PCA-based CBF
calibration of pCASL labeling efficiency may not be
justified at the single subject level.
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