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Abstract #0219

Pharmacokinetic Analysis for Differentiating Benign and Malignant Spinal Tumors Measured by DCE-MRI

Ning Lang 1 , Min-Ying Lydia Su 2 , Hon J Yu 2 , and Huishu Yuan 1

1 Department of Radiology, Peking University Third Hospital, Beijing, China, 2 Tu & Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States

DCE-MRI was performed to differentiate 4 spinal lesions (9 myeloma, 22 metastatic cancer, 7 lymphoma, 22 benign tuberculosis). The peak signal enhancement, the steepest wash-in slope and wash-out slope were measured. Two-compartmental pharmacokinetic model was used to obtain Ktrans and kep, by using three different blood curves (fast, medium, and slow). The results showed that kep analyzed by using fast or medium blood curves is the best parameter to differentiate these 4 lesion groups. Ktrans is associated with wash-in slope and kep is associated with wash-out slope. The slow blood curve is not suitable for a short DCE period.

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