Abstract #0220
DCE-MRI before and after induction chemotherapy in squamous cell carcinoma of the head and neck
Lucy E Kershaw 1 , Jonathan M Bernstein 2 , Stephanie B Withey 3 , Nicholas J Slevin 4 , Suzanne C Bonington 5 , Bernadette M Carrington 5 , and Catharine M West 2
1
Christie Medical Physics and Engineering,
The Christie NHS Foundation Trust, Manchester, Gtr
Manchester, United Kingdom,
2
Translational
Radiobiology Group, University of Manchester,
Manchester, Gtr Manchester, United Kingdom,
3
RRPPS63,
University Hospitals Birmingham, Birmingham, United
Kingdom,
4
Clinical
Oncology, The Christie NHS Foundation Trust, Manchester,
United Kingdom,
5
Radiology,
The Christie NHS Foundation Trust, Manchester, Gtr
Manchester, United Kingdom
This study investigated the changes in DCE-MRI
parameters due to induction chemotherapy for head and
neck squamous cell carcinoma. In RECIST responders,
extravascular-extracellular volume was significantly
different before and after therapy whereas in
non-responders it was not. A third examination at the
end of therapy, long-term followup and histological
markers of hypoxia might reveal further correlations
with early imaging.
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