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Abstract #0221

Quantifying variability in DCEMRI of the breast between 1.5T and 3T

Federico D. Pineda 1 , Milica Medved 1 , Xiaobing Fan 1 , Marko Ivancevic 2 , Hiroyuki Abe 1 , Akiko Shimauchi 1 , Charlene Sennet 1 , Gillian Newstead 1 , and Gregory S. Karczmar 1

1 Radiology, The University of Chicago, Chicago, IL, United States, 2 Philips Healthcare, Netherlands

DCEMRI of the breast is a valuable tool in the detection and staging of breast cancer. Radiologists rely on measures of uptake and washout of contrast media by analyzing the signal enhancement of suspicious lesions. Signal enhancement can vary due to scanner and acquisition parameters. Eleven volunteers were scanned at both 1.5T and 3T to quantify the variability in signal enhancement measures. We found that SER and time to peak enhancement had the lowest variability. Conversion from signal enhancement to concentration of contrast media did not significantly reduce variability, likely due to B1 inhomogeneity and uncertainty in native T1 estimation.

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