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Abstract #0224

Age-related abnormalities of white matter tracts in autism spectrum disorder: A diffusion spectrum imaging study using whole brain tract-specific analysis

Chien-Hung Lu 1 , Yu-Jen Chen 2 , Yu-Chun Lo 2 , Yung-Chin Hsu 2 , Susan Shur-Fen Gau 3,4 , and Wen-Yih Isaac Tseng 2,4

1 School of Medicine, National Taiwan University, Taipei, Taipei, Taiwan, 2 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taipei, Taiwan, 3 Department of Psychiatry, National Taiwan University College of Medicine, Taipei, Taipei, Taiwan, 4 Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taipei, Taiwan

This study aimed to investigate the differences of white matter tracts across a wide range of age between autism spectrum disorder and typically developing participants using diffusion spectrum imaging. In our findings, with a large sample size (63 : 63) and a broad range of age (7-29 years). GFA presented an atypical growth pattern in ASD compared to TD in several white matter tracts. The present data suggested that the time trajectory may differentiate brain maturation in ASD.

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