Age-related abnormalities of white matter tracts in autism spectrum disorder: A diffusion spectrum imaging study using whole brain tract-specific analysis
Chien-Hung Lu 1 , Yu-Jen Chen 2 , Yu-Chun Lo 2 , Yung-Chin Hsu 2 , Susan Shur-Fen Gau 3,4 , and Wen-Yih Isaac Tseng 2,4
School of Medicine, National Taiwan
University, Taipei, Taipei, Taiwan,
for Optoelectronic Medicine, National Taiwan University
College of Medicine, Taipei, Taipei, Taiwan,
of Psychiatry, National Taiwan University College of
Medicine, Taipei, Taipei, Taiwan,
Institute of Brain and Mind Sciences, National Taiwan
University, Taipei, Taipei, Taiwan
This study aimed to investigate the differences of white
matter tracts across a wide range of age between autism
spectrum disorder and typically developing participants
using diffusion spectrum imaging. In our findings, with
a large sample size (63 : 63) and a broad range of age
(7-29 years). GFA presented an atypical growth pattern
in ASD compared to TD in several white matter tracts.
The present data suggested that the time trajectory may
differentiate brain maturation in ASD.
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