Abstract #0224
Age-related abnormalities of white matter tracts in autism spectrum disorder: A diffusion spectrum imaging study using whole brain tract-specific analysis
Chien-Hung Lu 1 , Yu-Jen Chen 2 , Yu-Chun Lo 2 , Yung-Chin Hsu 2 , Susan Shur-Fen Gau 3,4 , and Wen-Yih Isaac Tseng 2,4
1
School of Medicine, National Taiwan
University, Taipei, Taipei, Taiwan,
2
Center
for Optoelectronic Medicine, National Taiwan University
College of Medicine, Taipei, Taipei, Taiwan,
3
Department
of Psychiatry, National Taiwan University College of
Medicine, Taipei, Taipei, Taiwan,
4
Graduate
Institute of Brain and Mind Sciences, National Taiwan
University, Taipei, Taipei, Taiwan
This study aimed to investigate the differences of white
matter tracts across a wide range of age between autism
spectrum disorder and typically developing participants
using diffusion spectrum imaging. In our findings, with
a large sample size (63 : 63) and a broad range of age
(7-29 years). GFA presented an atypical growth pattern
in ASD compared to TD in several white matter tracts.
The present data suggested that the time trajectory may
differentiate brain maturation in ASD.
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