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Abstract #0225

Diffusion MR of Auditory and Language Pathways in Children with 16p11.2 Deletions and Duplications

Jeffrey I Berman 1,2 , Darina Chudnovskaya 1 , Wendy K Chung 3 , John E Spiro 4 , Timothy PL Roberts 1,2 , and Simons VIP Consortium 4

1 Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3 Columbia University, New York, United States, 4 Simons Foundation, New York, New York, United States

Genetic copy number variation of 16p11.2 has been associated with developmental disorders such as autism spectrum disorders (ASD). This study uses diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI) to quantify microstructural alterations to the auditory radiation, Heschls gyrus, and arcuate fasciculus in children with 16p11.2 deletion or duplication. A significant effect of genetic copy number variation on FA, MD, and radial diffusivity was observed in each of the regions measured (p<0.05). Mean and radial diffusivities were consistently higher in the copy number variation groups indicating alterations of white matter microstructure which may impair function.

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