Abstract #0225
Diffusion MR of Auditory and Language Pathways in Children with 16p11.2 Deletions and Duplications
Jeffrey I Berman 1,2 , Darina Chudnovskaya 1 , Wendy K Chung 3 , John E Spiro 4 , Timothy PL Roberts 1,2 , and Simons VIP Consortium 4
1
Radiology, Children's Hospital of
Philadelphia, Philadelphia, PA, United States,
2
Radiology,
University of Pennsylvania, Philadelphia, PA, United
States,
3
Columbia University, New York, United
States,
4
Simons
Foundation, New York, New York, United States
Genetic copy number variation of 16p11.2 has been
associated with developmental disorders such as autism
spectrum disorders (ASD). This study uses diffusion
tensor imaging (DTI) and high angular resolution
diffusion imaging (HARDI) to quantify microstructural
alterations to the auditory radiation, Heschls gyrus,
and arcuate fasciculus in children with 16p11.2 deletion
or duplication. A significant effect of genetic copy
number variation on FA, MD, and radial diffusivity was
observed in each of the regions measured (p<0.05). Mean
and radial diffusivities were consistently higher in the
copy number variation groups indicating alterations of
white matter microstructure which may impair function.
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