Abstract #0226
Glutamate and GABA in Children with ADHD and Complex Motor Stereotypies: A 7T H MRS Study
Alena Horska 1 , Xin Wang 1 , Matthew Ryan 2 , Martha B Denckla 2 , Peter B Barker 1 , Harvey S Singer 1 , and E Mark Mahone 2
1
Johns Hopkins University, Baltimore, MD,
United States,
2
Kennedy
Krieger Institute, Baltimore, MD, United States
Using single voxel H MRS at 7T, concentrations of the
neurotransmitters glutamate (Glu) and GABA were measured
in prefrontal and fronto-striatal regions in pediatric
patients 5-10 years old, diagnosed with ADHD and complex
motor stereotypies (CMS). The control group was
comprised of age-matched healthy typically developing
children. Compared with controls, both patient groups
had a lower overall mean GABA/Cr ratio (calculated from
the 4 regions examined) and a lower striatal GABA/Cr
ratio. No group differences in the GABA/Cr and NAA/Cr
ratios were detected.
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