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Abstract #0228

Medication with Stimulants Modifies the Mean Diffusivity in Children with Attention Deficit/Hyperactivity Disorder: a DTI Study

Rodrigo de Luis-Garcia 1 , Gemma Cabus-Pinol 2 , Carlos Imaz-Roncero 2 , Daniel Argibay-Quinones 1 , Gonzalo Barrio-Arranz 1 , Santiago Aja-Fernandez 1 , and Carlos Alberola-Lopez 1

1 Laboratorio de Procesado de Imagen, Universidad de Valladolid, Valladolid, Valladolid, Spain, 2 Hospital Clinico Universitario, Valladolid, Valladolid, Spain

The impact of ADHD on white matter connectivity has not been well stablished yet, and the effects of treatment on the brain structure have not been sufficiently explored. We investigated the effects of ADHD and treatment with methylphenidate in the white matter of children using a tractography selection method that allows the robust extraction of several fiber bundles of interest. Differences in the Mean Diffusivity were found between ADHD patients under treatment and normal controls and between ADHD patients under treatment and drug-naive ADHD patients, indicating that the use of psychostimulants may modify the brain connectivity.

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