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Abstract #0229

Conduct disorder and callous unemotional traits are related to the microstructure of the dorsal default-mode network

Arjun Sethi 1 , Quinton Deeley 1 , Sagari Sarkar 1 , Marco Catani 1 , Flavio Dell'Acqua 1 , Declan DGM Murphy 1 , and Michael C Craig 1

1 Institute of Psychiatry, King's College London, London, England, United Kingdom

This work supports the importance of the white matter underpinning a mediodorsal component of the default-mode network (the dorsal cingulum) in conduct disorder and callous unemotional traits. Diffusion MRI tractography shows that decreased radial diffusivity in this tract portion is reduced in adolescents with conduct disorder, and that radial diffusivity is negatively correlated with callous-unemotional traits in the whole sample.

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