Non-Contrast Myocardial Fibrosis Imaging using MT-weighted Balanced Steady State Free Precession MRI

The development of myocardial fibrosis significantly heightens the risk of sudden cardiac death. Late gadolinium enhanced (LGE) MRI has become the reference standard for detection of fibrotic tissue, however, multiple high risk patient cohorts are contraindicated to LGE-CMR. We developed a novel fibrosis imaging technique that utilizes magnetization transfer (MT) from fibrotic tissue for completely non-invasive diagnosis of fibrotic remodeling. In this preliminary study, demonstrate excellent correlation of fibrosis as identified with MT-weighted bSSFP MRI with LGE-CMR and measurement of gadolinium partition coefficient.

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