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Abstract #0236

Electrical Characteristics of Chronic Iron-laden Myocardial Infarcts: Initial Study in Canine Hearts

Ivan Cokic 1 , Avinash Kali 2 , Xunzhang Wang 2 , Hsin-Jung Yang 2 , Richard L. Q. Tang 2 , Anees Thajudeen 2 , Michael Shehata 2 , Allen M. Amorn 2 , Enzhao Liu 2 , Brian Stewart 3 , Nathan Bennett 3 , Doron Harlev 3 , Sotirios A. Tsaftaris 4 , Warren M. Jackman 5 , Sumeet S. Chugh 2 , and Rohan Dharmakumar 2

1 Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2 Cedars-Sinai Medical Center, CA, United States, 3 Rhythmia Medical-Boston Scientific, Inc., MA, United States, 4 Institute for Advanced Studies, Lucca, Italy, 5 Heart Rhythm Institute, OK, United States

Myocardial infarction can lead to chronic iron deposition that can be accurately quantified with T2* MRI. However, its long-term fate and influence on myocardial electrical properties remain largely unexplored. In this study we used T2* MRI to characterize chronic iron deposition in canines with chronic myocardial infarction in combination with impedance spectroscopy, surface ECG indices and electroanatomical maps to demonstrate that the electrical behavior of infarcted hearts with iron appear to be different from those without iron.

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