Abstract #0237
Effects of Age and Smoking on Endothelial Function Assessed by Quantitative MRI in the Peripheral and Central Vasculature
Yongxia Zhou 1 , Michael C Langham 1 , Erica N Chirico 1,2 , Erin K Englund 1 , Emile R Mohler III 3 , Jeremy F Magland 1 , Wensheng Guo 4 , and Felix W Wehrli 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
School
of Nursing, University of Pennsylvania, Philadelphia,
PA, United States,
3
Medicine, University of
Pennsylvania, Philadelphia, PA, United States,
4
Biostatistics
and Epidemiology, University of Pennsylvania,
Philadelphia, PA, United States
The purpose was to assess various surrogates of
endothelial dysfunction using parameters derived from
dynamic MRI sequences. Measures of peripheral vascular
reactivity were assessed via dynamic venous oximetry,
arterial hyperemia and multi-segment pulse-wave velocity
(PWV) of thoracic and abdominal aorta in the form of a
single, integrated MR protocol in 132 subjects
consisting of young and old smokers and nonsmokers. Our
results demonstrate significant aging and smoking
effects based on parameters determined from dynamic MRI
measures, thereby providing new vascular biomarkers for
the effect of age and smoking on vascular endothelial
function.
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