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Abstract #0250

Multi-parametric MRI characterization of methylene blue treatment of mild Traumatic Brain Injury

Lora Talley Watts 1 , Justin Alexander Long 1 , Jonathan Chemello 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

This study investigated the spatiotemporal dynamics of diffusion, T2 and fractional anisotropy associated with mild traumatic brain injury (TBI) following methylene blue treatment. Lesion volume, diffusion, T2 and fractional anisotropy changes and behavioral scores generally correlated well with the improvement by methylene blue treatment compared to placebo controls. However, despite the presence of some lesions on day 7 and 14, behavioral measures mostly returned to normal in both groups, suggesting that there is functional compensation in our mild TBI model. Multi-parametric MRI offers a range of biomarkers that are sensitive to different tissue types and to different stages of TBI.

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