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Abstract #0253

Demonstration of Differentially Degenerated Corpus Callosam in Patients with Moderate Traumatic Brain Injury: With a Premise of Cortical-callosal Relationship

Kavita Singh 1 , Richa Trivedi 1 , Maria M Dsouza 1 , Ajay Chaudhary 2 , Pawan Kumar 1 , Ram KS Rathore 3 , Rajendra P Tripathi 1 , and Subash Khushu 1

1 Institute of Nuclear Medicine & Allied Sciences, Delhi, Delhi, India, 2 Dr. Ram Manohar Lohia Hospital, Delhi, Delhi, Delhi, India, 3 Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India

Aim our study was to assess the degenerative changes, secondary to TBI in subdivisional fibres of CC, corresponding to cortical brain area primarily injured in chronic moderate TBI patients. DTT was done in 18 TBI (A: frontal lobe injury,n=6; B: occipito-temporal lobe injury, n=5; C: fronto-parieto-temporal lobe injury, n=7) and 11 healthy participants. Diffusion metrices of 7 sub-divisions of CC (Witelsons scheme) were acquired using in-house developed software. The study showed significantly reduced FA and increased MD in the sub-divisions of CC corresponding to cortical brain area primarily injured. Reduced FA and increased MD values may represent regional Wallerian Degeneration.

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