Self-Regulation of Amygdala Activation with Real-Time fMRI Neurofeedback in Combat-Related PTSD
Raquel Phillips 1 , Vadim Zotev 1 , Han Yuan 1 , Kymberly Young 1 , Chung Ki Wong 1 , Brent Wurfel 1 , Frank Krueger 1,2 , Matthew Feldner 1,3 , and Jerzy Bodurka 1,4
Laureate Institute for Brain Research,
Tulsa, OK, United States,
Dept., George Mason University, Fairfax, VA, United
Department of Psychological Science,
University of Arkansas, Fayetteville, AR, United States,
of Engineering, University of Oklahoma, Tulsa, OK,
Post-traumatic stress disorder (PTSD) is a chronic and
disabling psychiatric condition. Individuals with PTSD
suffer from the dysregulation of several types of
emotion including fear, anxiety, and depression.
Neurocircuit models of PTSD emphasize the role of the
amygdala. We utilize advances in real-time functional
magnetic resonance imaging neurofeedback (rtfMRI-nf) to
directly modulate amygdala activity. This technique
measures neuronal activity with sufficiently high
temporal resolution that information from the amygdala
is immediately available to form a feedback loop. We
show that individuals with PTSD are able to use
rtfMRI-nf training to enhance the control of the
hemodynamic response of the amygdala.
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