Abstract #0256
Age-related hypermetabolism in the human brain
Shin-Lei Peng 1,2 , Julie Dumas 3 , Denise Park 1,4 , Peiying Liu 1 , Francesca Filbey 4 , Carrie McAdams 1 , Amy Pinkham 1,5 , Bryon Adinoff 1,6 , Rong Zhang 7 , and Hanzhang Lu 1
1
UT Southwestern Medical Center, Dallas, TX,
United States,
2
National
Tsing Hua University, Taiwan,
3
University
of Vermont College of Medicine, VT, United States,
4
University
of Texas Dallas, TX, United States,
5
Southern
Methodist University, TX, United States,
6
VA
North Texas Health Care System, Dallas, TX, United
States,
7
Texas
Health Presbyterian Hospital Dallas, TX, United States
In this study, we provide evidence that the brain of
older adults works harder when compared to younger
adults, as manifested by an age-related increase in
cerebral metabolic rate of oxygen (CMRO2) (N=118). We
further showed that, prior to the typical menopausal age
of 51 years old, female and male groups have similar
rates of CMRO2 increase (P=0.003). However, for the
entire age range, women have a slower rate of CMRO2
change, when compared to men (P<0.001). Our data also
revealed a possible circadian rhythm of CMRO2 in that
brain metabolic rate is greater at noon than in the
morning.
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