Abstract #0257
More frequent cognitive activity in late life is associated with higher brain microstructural integrity in non-demented older adults
C. M. Barth 1 , R. S. Wilson 2 , A. Capuano 2 , S. Zhang 2 , D. A. Bennett 2 , and K. Arfanakis 1
1
Department of Biomedical Engineering,
Illinois Institute of Technology, Chicago, Illinois,
United States,
2
Rush
Alzheimer's Disease Center, Rush University Medical
Center, Chicago, Illinois, United States
The purpose of this study was to test the hypotheses
that: a) more frequent cognitive activity in late life
is associated with higher microstructural integrity in
brain white matter (WM), and b) microstructural
integrity in WM mediates the relation between late life
cognitive activity and cognition. Diffusion tensor
imaging data were collected for a community-dwelling
sample of 397 older, non-demented adults. It was
demonstrated that fractional anisotropy in a number of
WM regions was significantly associated with frequency
of late life cognitive activity. Also, FA in those WM
regions partially mediated the relationship between late
life cognitive activity and cognition.
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