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Abstract #0258

Neural mechanisms of brain plasticity with cognitive training in healthy seniors

Sina Aslan 1,2 , Sandra B Chapman 2 , Jeffrey S Spence 2 , Molly Keebler 2 , Nyaz Didehbani 2 , and Hanzhang Lu 3

1 Advance MRI, LLC, Frisco, Texas, United States, 2 Center for BrainHealth, University of Texas at Dallas, Dallas, Texas, United States, 3 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States

This study investigates that engaging in complex mental activity offer promising ways to enhance brain integrity to promote successful cognitive aging. Using three MRI-based measurements, i.e. pCASL MRI, fcMRI, and DTI, we examined brain changes across three time points pre, mid, and post-training (12-weeks) in a randomized sample who received cognitive training versus a control group. We found significant training-related brain state changes at rest; specifically, (1) increases in global and regional CBF, particularly in the default mode and central executive networks, (2) greater connectivity in these same networks, and (3) increased white matter integrity in the left uncinate fasciculus.

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