Abstract #0259
Reduced fractional anisotropy in ageing: Is it driven by changes in tissue microstructure or by partial volume effects?
Johan Westborg 1 , Danielle Van Westen 1,2 , Markus Nilsson 3 , Jimmy Ltt 2 , Filip Szczepankiewicz 4 , Sebastian Palmqvist 5 , Erik Stomrud 5 , Lennart Minthon 5 , Katarina Ngga 5 , and Oskar Hansson 5
1
Department of Diagnostic Radiology, Lund
University, Lund, Sweden,
2
Center
for Medical Imaging and Physiology, Skane University
Hospital, Lund, Sweden,
3
Lund
University Bioimaging Center, Lund University, Lund,
Sweden,
4
Department
of Medical Radiation Physics, Lund University, Lund,
Sweden,
5
Clinical Memory Research Unit,
Clinical Sciences, Lund University, Malm, Sweden
Our aim was to disentangle the contribution of
microstructural change and partial volume effects (PVE)
to the reduction of the fractional anisotropy (FA) in
the corpus callosum, observed in ageing. Using
tractography, we show that the FA reduction with age
becomes non-significant when the voxel-count in the
tract segments is corrected for. An observed FA
reduction in older (>71 years) subjects with ventricular
enlargement was primarily driven by increased callosal
atrophy. We did not observe microstructural change
separate from atrophy and increased PVE.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
