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Abstract #0271

NODDI performs better than DTI in brain tumors with vasogenic edema

Matteo Figini 1,2 , Giuseppe Baselli 1 , Marco Riva 3 , Lorenzo Bello 4,5 , Hui Zhang 6 , and Alberto Bizzi 7

1 Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, MI, Italy, 2 Scientific Direction, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, MI, Italy, 3 Neurosurgery, Universit degli Studi di Milano, Milano, MI, Italy, 4 Surgical Neuro-Oncology Unit, Humanitas Clinical and Research Center, Rozzano, MI, Italy, 5 Department of Medical Biotechnology and Translational Medicine, Universit degli Studi di Milano, Milano, MI, Italy, 6 Department of Computer Science and Centre for Medical Image Computing, University College London, London, United Kingdom, 7 Neuroradiology, Humanitas Clinical and Research Center, Rozzano, MI, Italy

In this work we developed a procedure to perform NODDI-based tractography with an ODI threshold equivalent to the commonly used FA = 0.2 in order to fairly compare the results with those from DTI-based tractography; the aim is to investigate the advantages of performing tractography based on fiber directions and microstructural parameters estimated by NODDI. Our preliminary results showed a higher track density in areas infiltrated by brain tumours with NODDI than with DTI. The advantage of NODDI-based tractography appears to be most evident in areas of vasogenic edema.

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