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Abstract #0277

Characterizing white matter pathways of the living rat brain by Tractometry

Daniel Barazany 1,2 , Silvia De Santis 1,2 , Mara Cercignani 3 , Yaniv Assaf 2 , and Derek K Jones 1

1 School of Psychology, Cardiff University, Cardiff, United Kingdom, 2 Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel, 3 Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Falmer, East Sussex, United Kingdom

Tractometry framework aims to establish more accurate and informative description of white matter brain tissue by on exploiting imaging methods which provide higher sensitivity to the underlying tissue subcomponents such as the composite hindered and restricted model of diffusion (CHARMED) and qMT. In this work we utilized tractometry microstructural metrics to examine and characterize two different white matter pathways of the living rat brain, the corpus callosum and the fimbria. We show the high sensitivity of these metrics to differentiate between the two fibers.

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