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Abstract #0276

Cortical parcellation based on DTI connectivity--validation in the squirrel monkey brain

Yurui Gao 1,2 , Andrew J Plassard 3 , Ann Choe 2,4 , Iwona Stepniewskwa 5 , Xia Li 4 , Bennett A Landman 4,6 , and Adam W Anderson 2,4

1 VUIIS, Vanderbilt University, Nashville, Tennessee, United States, 2 BME, Vanderbilt University, TN, United States, 3 Computer Science, Vanderbilt University, TN, United States, 4 VUIIS, Vanderbilt University, TN, United States, 5 Psychology, Vanderbilt University, TN, United States, 6 Electrical Engineering, Vanderbilt University, TN, United States

Diffusion MRI has been proposed as a method to parcellate cortex into functionally distinct regions based on tractography-derived connectivity features. However, the accuracy of the parcellation has not been investigated extensively. This study aimed to validate DTI connectivity-based cortical parcellation by comparison to a histological gold-standard. The comparison reveals the potential and limitations of connectivity-based parcellation.

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