Abstract #0275
Perforant pathway tracking in human temporal lobe ex vivo tissue.
Luis Manuel Colon-Perez 1 , Mansi Parekh 2 , Michelle Couret 3 , Rosemary Klassen 3 , Michael King 4 , Paul Carney 5 , and Thomas Mareci 1
1
Biochemistry and Molecular Biology,
University of Florida, Gainesville, FL, United States,
2
Radiology,
Stanford University, Stanford, CA, United States,
3
University
of Florida, FL, United States,
4
Pharmacology
and Therapeutics, University of Florida, FL, United
States,
5
Pediatrics,
University of Florida, FL, United States
The perforant pathway is a bundle of axons that provide
direct connections from the entorhinal cortex (EC) to
all subfields of the hippocampus (HC). This pathway is a
complicated structure difficult to visualize in clinical
data. In order to study this pathway, we acquired high
spatial resolution diffusion weighted images of excised
human tissue, which reduce volume averaging enhancing
the ability to resolve this small fiber pathway and
employ an advanced model of diffusion displacement which
improve tracking for smaller fiber bundles by resolving
crossing and kissing fibers. In this study we visualize
this pathway using probabilistic and deterministic
tractography.
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