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Abstract #0274

Improved tractography of post mortem human brain at 7T using DWSSFP

Sean Foxley 1 , Saad Jbabdi 1 , Wilfred Lam 1 , Olaf Ansorge 2 , Gwenaelle Douaud 1 , and Karla Miller 1

1 FMRIB Centre, University of Oxford, Oxford, OXON, United Kingdom, 2 University of Oxford, Oxford, OXON, United Kingdom

Post-mortem human brain imaging at 3T using diffusion-weighted steady state free precession (DWSSFP) has been demonstrated to provide improved data for tractography compared with diffusion weighted spin echo data. Here, DWSSFP was used to acquire diffusion data of post-mortem human brain at 7T. Tractography results produced from this data demonstrated increased prevalence of secondary fiber estimates compared with equivalent data acquired at 3T. Better estimates from 7T data provided improved results in tracts that encounter intersecting pathways; specifically those that project through the centrum semiovale. These projecting tracts detected in 7T data are largely unseen in 3T data.

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