An in-vivo 1H MRS study of metabolic correlation in IDH1 vs. IDH2 mutated gliomas

Isocitrate dehydrogenases (IDH) 1 and 2 catalyze the NADP+ dependent conversion of isocitrate to -ketoglutarate in the cytosol and mitochondria, respectively. The mutations in these enzymes result in the production of 2-hydroxyglutarate (2HG). We have investigated metabolic correlations in IDH1- vs. IDH2-mutated gliomas (28 and 5 patients, respectively) focusing on 2HG in vivo, using 1H MRS at 3T. Data indicated 2HG levels were highly correlated with choline, NAA, creatine and glutamate. The correlations were stronger in IDH2 mutated gliomas than in IDH1 mutated gliomas.

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