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Abstract #0289

Towards Improved Characterization of Brain Tumors by 23 Na-MR Neuroimaging at 7 Tesla

Armin Biller 1,2 , Jens Kleesiek 3 , Jan Oliver Neumann 3 , Felix Sahm 4 , Anne Dorothea Hertenstein 3 , and Armin Michael Nagel 5

1 Neuroradiology, University of Heidelberg, Heidelberg, Badem-Wrttemberg, Germany, 2 Radiology, German Cancer Research Center DKFZ, Heidelberg, Badem-Wrttemberg, Germany, 3 University of Heidelberg, Baden-Wrttemberg, Germany, 4 Neuropathology, Baden-Wrttemberg, Germany, 5 Medical Physics in Radiology, German Cancer Research Center DKFZ, Baden-Wrttemberg, Germany

In this study we demonstrate a robust correlation between the Ki-67 proliferation index of brain tumor cells and the relaxation weighted 23 Na contrasts (NaR and NaS). Both contrasts represent the signal of ions with short relaxation times. The NaT contrast, which reflects the tissue sodium concentration, exhibited no association with histopathology. Also, statistical analyses revealed no correlation between the Ki-67 index and canonical 1 H-MRI including T1w gadolinium enhanced, T2w and FLAIR imaging. These results emphasize the added benefit of 23 Na-MRI to conventional 1 H imaging in neurooncology. Of note, in contrast to 1 H neuroimaging in oncology 23 Na-MRI requires no contrast media.

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