Abstract #0290
Intratracheal administration of Gd-based nanoparticles: an effective approach for MRI detection and follow-up of lung tumor
Andrea Bianchi 1 , Sandrine Dufort 2,3 , Franois Lux 4 , Nawal Tassali 1 , Pierre-Yves Fortin 1 , Olivier Tillement 4 , Jean-Luc Coll 2 , and Yannick Crmillieux 1
1
Centre de Rsonance Magntique des Systmes
Biologiques, Universit Bordeaux Segalen, Bordeaux,
Bordeaux, France,
2
Universit
Joseph Fourier, Grenoble, France,
3
Nano-H,
Saint Quentin-Fallavier, France,
4
Institut
Lumire Matire, Universit Claude Bernard, Lyon, France
Lung cancer is the leading cause of cancer deaths
worldwide. The burden of this disease could be greatly
reduced with an early diagnostics. We present here an in
vivo MRI longitudinal study of lung cancer detection in
tumor-bearing mice through intratracheally- and
intravenously-administered multimodal Ultra-Small Rigid
Platforms and a commercial Gd-based contrast agent. The
localization of the tumors was validated against
bioluminescence imaging and histology. In this study we
showed for the first time that the synergic employment
of a strongly T1-weighted MRI UTE sequence and high-relaxivity
gadolinium-based nanoparticles allow the high-precision
detection of lung tumor and of its contours.
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