Abstract #0296
Ultra-short echo-time MRI distinguishes ischemia/reperfusion injury from acute rejection in a mouse lung transplantation model
Natalie Christine Chuck 1 , Wolfgang Jungraithmayr 2 , Moritz Wurnig 1 , Markus Weiger 3 , and Andreas Boss 1
1
Institute for Diagnostic and Interventional
Radiology, University Hospital Zrich, Zrich, Zrich,
Switzerland,
2
Division
of Thoracic Surgery, University Hospital Zrich, Zrich,
Switzerland,
3
Institute
for Biomedical Engineering, Swiss Federal Institute for
Technology Zrich, Zrich, Zrich, Switzerland
In this study we wanted to show that ultrashort
echo-time sequences are capable of identifying and
characterizing changes in the lung parenchyma that
appear after allogeneic lung transplantation. We used a
mouse model and compared the allogeneic transplanted
mice to syngeneic transplanted group in order to
differentiate the changes from ischemia/reperfusion
injury which also often occurs after lung
transplantation. Therefore we scanned the animals on
three different time points after the transplantation
using conventional T2 sequences as well as UTE sequences
with different echo times.
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