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Abstract #0303

In-Vivo Assessment of Multi-Component Relaxation of Articular Cartilage using mcRISE at 3.0T

Fang Liu 1 , Alexey Samsonov 1 , Pouria Mossahebi 2 , Rajeev Chaudhary 2 , Wally Block 1,2 , and Richard Kijowski 3

1 Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, United States, 2 Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States, 3 Department of Radiology, University of Wisconsin-Madison, Wisconsin, United States

A new technique named multi-component Relaxation Imaging using Steady-state signal Evolution (mcRISE) was proposed in this study to resolve unbiased and magnetization transfer (MT) corrected multi-component T2 measures. Our technique introduces a macromolecular proton pool in exchange with regular two component water pools and uses a combined model aimed for providing more robust and unbiased multi-component T2 values along with additional quantitative MT parameters, which may provide a new set of biomarkers for assessing the cartilage extracellular matrix in-vivo.

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