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Abstract #0334

High angularly resolved diffusion imaging with accelerated multi-shot acquisition and compressed sensing

Tzu-Cheng Chao 1,2 , Jr-Yuan George Chiou 3 , Stephan E. Maier 3 , and Bruno Madore 3

1 Department of Computer Science and Information Engineering, National Cheng-Kung University, Tainan, Taiwan, 2 Institute of Medical Informatics, Naitonal Cheng-Kung University, Tainan, Taiwan, 3 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

High angularly resolved diffusion imaging is a well-established strategy to help resolve fiber crossings and enable tractography. Long scan times and the presence of geometrical distortion in the resulting images may be the main factors currently limiting its clinical use. In the present work, methods are combined for accelerating the acquisition process in k-space (to reduce distortion) as well as in the diffusion-encoding space (to reduce scan time). As compared to a non-accelerated protocol, results are presented that offer a four-fold reduction in distortion as well as a reduction by about 40% in scan time.

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