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Abstract #0335

Fast B1-insensitive T2 relaxometry of the human brain at high to ultra-high fields

Rahel Heule 1 , Peter Br 2 , Christian Mirkes 3,4 , Klaus Scheffler 3,4 , Siegfried Trattnig 2 , and Oliver Bieri 1

1 Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 2 MR Centre of Excellence, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3 MRC Department, Max Planck Institute for Biological Cybernetics, Tbingen, Germany, 4 Department of Biomedical Magnetic Resonance, University of Tbingen, Tbingen, Germany

Quantitative imaging at high to ultra-high fields suffers from prominent B1 field inhomogeneities that affect quantification accuracy. Recently, a 3D triple echo steady-state (TESS) approach has been presented that offers fast B1-insensitive T2 quantification. In this work, the sensitivity to subject motion of 3D-TESS is reduced by investigating a rapid 2D technique suited for brain applications. The feasibility and reliability of 2D TESS-T2 relaxometry is demonstrated in human brain scans at high (3 T) and ultra-high (7 T and 9.4 T) fields. The results accentuate the potential of TESS-T2 to act as valuable measure for the detection of brain tissue alterations.

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