Abstract #0346
Evaluation of Lesion Severity in Transient MCAO Rat Brain During Early Reperfusion Using Combined Cerebral Vascular Reactivity and Diffusion Imaging
Xiao Wang 1 , Xiao-Hong Zhu 1 , Afshin A Divani 2 , Yi Zhang 1 , and Wei Chen 1
1
Center for Magnetic Resonance
Research, Department of Radiology, University of
Minnesota Medical School, Minneapolis,
Minnesota, United States,
2
Neurology,
University of Minnesota, Minnesota, United
States
Ischemic stroke is a leading cause of death and
long-term disability in the United States.
Tremendous effort has been taken and great
progress has been made to detect and treat the
ischemic lesion at an early stage. The use of
thrombolytic agent such as tissue plasminogen
activator (tPA) can be helpful to restore the
function of salvageable tissues, however,
reperfusion paradoxically may also lead to the
secondary cell death concurrently. The severity
of the reperfusion lesion was evaluated with the
ADC, CVR images at a relatively early stage (24
hours after a 1-hour MCA occlusion) of rat brain
and the corresponding histology images were
obtained on day 7 of the post-occlusion. The
results show that the spatial pattern of
declined ADC correlates well with the actual
lesion region determined by the histology
images, while the compromised CVR with normal
ADC turns out to be histologically intact.
Therefore, three regions regarding the lesion
severity can be identified with combined ADC and
CVR images: severe lesion region with both ADC
and CVR decreased; mild lesion region with
impaired CVR but normal ADC and the normal brain
region with intact CVR and ADC. The mismatched
areas with compromised CVR but intact ADC at the
early stage of reperfusion potentially could
serve as the treatment target to improve the
clinical outcomes.
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