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Abstract #0347

Activation induced BOLD and CBF responses upon acetazolamide administration: implications for inferring neurovascular and metabolic coupling in patients with impaired cerebrovascular reactivity

Jeroen C.W. Siero 1 , Nolan Hartkamp 1 , Anita A. Harteveld 1 , Annette Compter 1 , Bart van der Worp 1 , Manus J. Donahue 2 , Esben T. Petersen 1 , and Jeroen Hendrikse 1

1 University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Radiology and Radiological Sciences, Vanderbilt University, TN, United States

We acquired CBF and BOLD data in patients with cerebrovascular disease (stenosis/occlusion of vertebral basilar artery) during visual stimulation before and after acetazolamide (ACZ) administration. One third of the patients showed negative BOLD responses post-ACZ while CBF remained positive. As the conventionally assumed one-to-one relationship between BOLD and CBF responses seems compromised, caution is warranted when inferring cortical activation and neurovascular coupling in these patients when solely using BOLD fMRI. Our findings indicate altered neurovascular and/or metabolic coupling in these patients and could potentially be valuable marker for clinical outcome.

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