Abstract #0347
Activation induced BOLD and CBF responses upon acetazolamide administration: implications for inferring neurovascular and metabolic coupling in patients with impaired cerebrovascular reactivity
Jeroen C.W. Siero 1 , Nolan Hartkamp 1 , Anita A. Harteveld 1 , Annette Compter 1 , Bart van der Worp 1 , Manus J. Donahue 2 , Esben T. Petersen 1 , and Jeroen Hendrikse 1
1
University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands,
2
Radiology
and Radiological Sciences, Vanderbilt
University, TN, United States
We acquired CBF and BOLD data in patients with
cerebrovascular disease (stenosis/occlusion of
vertebral basilar artery) during visual
stimulation before and after acetazolamide (ACZ)
administration. One third of the patients showed
negative BOLD responses post-ACZ while CBF
remained positive. As the conventionally assumed
one-to-one relationship between BOLD and CBF
responses seems compromised, caution is
warranted when inferring cortical activation and
neurovascular coupling in these patients when
solely using BOLD fMRI. Our findings indicate
altered neurovascular and/or metabolic coupling
in these patients and could potentially be
valuable marker for clinical outcome.
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