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Abstract #0348

Quantifying cerebral haemodynamics and maximum potential oxygen delivery in patients with chronic ischemia using DSC perfusion MRI

Amit Mehndiratta 1 , Chang Sub Park 1 , David E Crane 2 , Bradley J MacIntosh 2 , Stephen J Payne 1 , and Michael A Chappell 1

1 Institute of Biomedical Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada

Estimation of capillary haemodynamics has historically been a challenge in DSC-MRI analysis. With the Control Point Interpolation method it is now possible to study variation in residue function and haemodynamics in-vivo. This study examined the changes in tissue haemodynamics, maximum potential oxygen delivery corresponding maximum potential tissue metabolic activity in a cohort of seventeen patients with atherosclerotic diseases both pre- and post-carotid endarterectomy. It was found that capillary heterogeneity increased in ischemic tissue, which would be associated with an increase in maximum tissue oxygen extraction fraction that could assist the tissue to maintain normal metabolic activity.

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