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Abstract #0350

Alterations in Cerebrovascular Reactivity across the Adult Lifespan: a 4-year Follow-up

Yang Li 1 , Denise C. Park 2 , Karen M. Rodrigue 2 , Yamei Cheng 1 , and Hanzhang Lu 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Center for Vital Longevity, School of Behavioral and Brain Sciences, Uiversity of Texas at Dallas, Dallas, Texas, United States

Age is the single most important risk factor for stroke and associated cerebrovascular diseases. To date, the most direct vascular marker in vivo has been shown to be cerebrovascular reactivity (CVR), which reflects the ability of the vessel to dilate when challenged. In this work, we present four-year longitudinal follow-up CVR data in 80 healthy individuals ranging from 20 to 85 years old. The findings from the longitudinal data were compared to those from the cross-sectional data. Regional differences were also investigated.

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