Exercise-related changes in hippocampal and white matter structures: A longitudinal MRI and serum marker study
Karsten Mueller 1 , Harald E Mller 1 , Franziska Busse 1 , Annette Horstmann 1,2 , Jran Lepsien 1 , Matthias L Schroeter 1,3 , Matthias Blher 2,4 , Michael Stumvoll 4 , Arno Villringer 1,3 , and Burkhard Pleger 1,3
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
Research and Treatment Center (IFB) Adiposity Diseases,
Clinic for Cognitive Neurology, University Hospital
for Internal Medicine, University Hospital Leipzig,
We investigated the effect of intense physical exercise
on brain structure in relation to the brain-derived
neurotrophic factor (BDNF), leptin and high-density
lipoprotein (HDL) serum concentrations in 16 young
overweight and obese participants. After a 3-months
fitness program, we found a significant decrease of
leptin and an increase of HDL and BDNF. Structural MRI
was performed directly after blood withdrawal.
Significant correlations were found between the
intra-individual changes in serum markers concentration
and grey matter density, particularly in the left
hippocampus, and radial diffusivity in large white
matter regions including the whole corpus callosum.
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