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Abstract #0351

Exercise-related changes in hippocampal and white matter structures: A longitudinal MRI and serum marker study

Karsten Mueller 1 , Harald E Mller 1 , Franziska Busse 1 , Annette Horstmann 1,2 , Jran Lepsien 1 , Matthias L Schroeter 1,3 , Matthias Blher 2,4 , Michael Stumvoll 4 , Arno Villringer 1,3 , and Burkhard Pleger 1,3

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig, Germany, 3 Day Clinic for Cognitive Neurology, University Hospital Leipzig, Germany, 4 Department for Internal Medicine, University Hospital Leipzig, Germany

We investigated the effect of intense physical exercise on brain structure in relation to the brain-derived neurotrophic factor (BDNF), leptin and high-density lipoprotein (HDL) serum concentrations in 16 young overweight and obese participants. After a 3-months fitness program, we found a significant decrease of leptin and an increase of HDL and BDNF. Structural MRI was performed directly after blood withdrawal. Significant correlations were found between the intra-individual changes in serum markers concentration and grey matter density, particularly in the left hippocampus, and radial diffusivity in large white matter regions including the whole corpus callosum.

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