Abstract #0351
Exercise-related changes in hippocampal and white matter structures: A longitudinal MRI and serum marker study
Karsten Mueller 1 , Harald E Mller 1 , Franziska Busse 1 , Annette Horstmann 1,2 , Jran Lepsien 1 , Matthias L Schroeter 1,3 , Matthias Blher 2,4 , Michael Stumvoll 4 , Arno Villringer 1,3 , and Burkhard Pleger 1,3
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
2
Integrated
Research and Treatment Center (IFB) Adiposity Diseases,
Leipzig, Germany,
3
Day
Clinic for Cognitive Neurology, University Hospital
Leipzig, Germany,
4
Department
for Internal Medicine, University Hospital Leipzig,
Germany
We investigated the effect of intense physical exercise
on brain structure in relation to the brain-derived
neurotrophic factor (BDNF), leptin and high-density
lipoprotein (HDL) serum concentrations in 16 young
overweight and obese participants. After a 3-months
fitness program, we found a significant decrease of
leptin and an increase of HDL and BDNF. Structural MRI
was performed directly after blood withdrawal.
Significant correlations were found between the
intra-individual changes in serum markers concentration
and grey matter density, particularly in the left
hippocampus, and radial diffusivity in large white
matter regions including the whole corpus callosum.
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