Abstract #0354
Changes in Resting-State fMRI Activity during Salicylate-Induced Tinnitus and Sound Stimulation
Yu-Chen Chen 1 , Jian Wang 2,3 , Yun Jiao 1 , Richard Salvi 4 , and Gao-Jun Teng 1
1
Jiangsu Key Laboratory of Molecular Imaging
and Functional Imaging, Department of Radiology, Zhongda
Hospital, Medical School of Southeast
University,Nanjing,China, Nanjing, Jiangsu, China,
2
Department
of Physiology and Pharmacology, Medical School of
Southeast University,Nanjing,China, Nanjing, Jiangsu,
China,
3
School
of Human Communication Disorders, Dalhousie University,
Halifax, Nova Scotia, Canada, Nova Scotia, Canada,
4
Center
for Hearing and Deafness, University at Buffalo,
Buffalo, NY, USA, New York, United States
Recent studies suggest that low frequency neural
oscillatory activity contributes to tinnitus generation.
To explore this issue, we measured the amplitude of
low-frequency fluctuations (ALFF) in resting-state
functional magnetic resonance imaging (fMRI) during
salicylate-induced tinnitus and during sound
stimulation. We found that salicylate significantly
increased ALFF oscillatory activity in several auditory
and non-auditory regions previously implicated in
tinnitus. Music stimulation tended to potentiate the
salicylate-induced hyperactivity in the ALFF responses
in many auditory areas. Resting-state ALFF fMRI might be
used to identify the aberrant neural networks in humans
who suffer from severe, debilitating tinnitus.
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