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Abstract #0354

Changes in Resting-State fMRI Activity during Salicylate-Induced Tinnitus and Sound Stimulation

Yu-Chen Chen 1 , Jian Wang 2,3 , Yun Jiao 1 , Richard Salvi 4 , and Gao-Jun Teng 1

1 Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University,Nanjing,China, Nanjing, Jiangsu, China, 2 Department of Physiology and Pharmacology, Medical School of Southeast University,Nanjing,China, Nanjing, Jiangsu, China, 3 School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada, Nova Scotia, Canada, 4 Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA, New York, United States

Recent studies suggest that low frequency neural oscillatory activity contributes to tinnitus generation. To explore this issue, we measured the amplitude of low-frequency fluctuations (ALFF) in resting-state functional magnetic resonance imaging (fMRI) during salicylate-induced tinnitus and during sound stimulation. We found that salicylate significantly increased ALFF oscillatory activity in several auditory and non-auditory regions previously implicated in tinnitus. Music stimulation tended to potentiate the salicylate-induced hyperactivity in the ALFF responses in many auditory areas. Resting-state ALFF fMRI might be used to identify the aberrant neural networks in humans who suffer from severe, debilitating tinnitus.

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