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Abstract #0355

Association between Mothers Depression and Childrens Hippocampal Shape Analyzed Using Non-Rigid Registration

Peter T. Fwu 1 , Elysia P. Davis 2 , Claudia Buss 2 , Muqing Lin 1 , Kevin Head 2 , Curt A. Sandman 2 , and Min-Ying Lydia Su 1

1 Tu & Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States, 2 Women and Childrens Health and Well-Being Project, Department of Psychiatry & Human Behavior, University of California, Irvine, CA, United States

Hippocampal volume and shape analysis was applied to 103 children (6-10 years old) to evaluate the association with prenatal and post-partum depression of their mothers during and after pregnancy. Non-rigid registration was applied to analyze shape based on the deformation matrix. The head segment of the right hippocampus showed a significant association with prenatal depression, and the body segment of the left hippocampus showed a significant correlation with the post-partum depression. The results were similar in males and females. None of the volumetric measurements revealed significant correlations, suggesting that shape analysis may provide a more sensitive tool for subregional analysis.

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