Abstract #0355
Association between Mothers Depression and Childrens Hippocampal Shape Analyzed Using Non-Rigid Registration
Peter T. Fwu 1 , Elysia P. Davis 2 , Claudia Buss 2 , Muqing Lin 1 , Kevin Head 2 , Curt A. Sandman 2 , and Min-Ying Lydia Su 1
1
Tu & Yuen Center for Functional
Onco-Imaging, Department of Radiological Sciences,
University of California, Irvine, CA, United States,
2
Women
and Childrens Health and Well-Being Project, Department
of Psychiatry & Human Behavior, University of
California, Irvine, CA, United States
Hippocampal volume and shape analysis was applied to 103
children (6-10 years old) to evaluate the association
with prenatal and post-partum depression of their
mothers during and after pregnancy. Non-rigid
registration was applied to analyze shape based on the
deformation matrix. The head segment of the right
hippocampus showed a significant association with
prenatal depression, and the body segment of the left
hippocampus showed a significant correlation with the
post-partum depression. The results were similar in
males and females. None of the volumetric measurements
revealed significant correlations, suggesting that shape
analysis may provide a more sensitive tool for
subregional analysis.
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