Diffusion tensor and magnetization transfer imaging of tumor margin in a rat C6 Glioma Model
Monika Huhndorf 1 , Olga Will 2 , Rolf Mentlein 3 , Olav Jansen 1 , and Susann Boretius 2
Department of Radiology and Neuroradiology,
University Medical Center Schleswig-Holstein, Kiel,
Biomedical Imaging, Department of Radiology and
Neuroradiology, Christian-Albrechts-University, Kiel,
Institute, Christian-Albrechts-University, Kiel, Germany
Glioblastoma multiforme is the most malignant brain
tumor with an infaust prognosis and still a therapeutic
challenge, because of its infiltrative tumor growth.
Visualizing tumor-cell infiltration non-invasively has
been focused by many scientists. Since infiltration
starts at the tumor margin, we focused on imaging of
this area in a rat C6-glioma model at 7T MRI using
diffusion tensor and magnetization transfer imaging. We
observed an increase in fractional anisotropy and MT
saturation at the tumor margin beyond the tumor region
visible on T2-weighted images indicating structural
changes in peritumoral tissue.
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