High Cellularity Subvolume in Glioblastoma identified by High b-value Diffusion Weighted Images
Priyanka P Pramanik 1 , Hemant A Parmar 2 , Aaron G Mammoser 3 , Larry R Junck 3 , Theodore S Lawrence 1 , Christina I Tsien 1 , and Yue Cao 1
Department of Radiation Oncology, University
of Michigan, Ann Arbor, MI, United States,
of Radiology, University of Michigan, Ann Arbor, MI,
of Neurology, University of Michigan, Ann Arbor, MI,
The blood-brain(tumor)-barrier could impact therapeutic
efficacy of glioblastoma, particularly in the
non-enhanced component, which is difficult to
differentiate from edema using conventional MRI. This
study explores high b-value Diffusion Weighted Imaging (DWI)
as a means to identifying the non-enhanced solid tumor.
Our study shows that a large non-enhanced high cellular
tumor volume extracted from b=3000 s/mm^2 DWI is
associated with a higher likelihood of non-central
recurrence. High b-value DWI shows promise for aiding in
radiation therapy target volume definition.
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