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Abstract #0370

In vivo spectroscopic imaging of citrate in gliomas at 3.0 T

Sandeep K Ganji 1,2 , Akshay Madan 1 , Zhongxu An 1 , Elizabeth A Maher 3,4 , and Changho Choi 1,2

1 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3 Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 4 Harold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States

Joint Annual Meeting ISMRM-ESMRMB 2014 10-16 May 2014 Milan, Italy

Hepatobiliary 2

Tuesday 13 May 2014
Blue 1 & 2 13:30 - 15:30 Moderators: Zoran Stankovic, M.D., Bachir Taouli, M.D.

13:30 0371. Advanced Assessment of Liver Diseases with Magnetic Resonance Elastography in Mouse Models
Meng Yin 1 , Douglas A. Simonetto 2 , Jason L. Bakeberg 3 , Anuradha Krishnan 2 , Kevin J. Glaser 1 , Vijay H. Shah 2 , Christopher J. Ward 3 , Peter C. Harris 3 , Michael R. Charlton 2 , Armando Manduca 1 , and Richard L. Ehman 1
1 Radiology, Mayo Clinic, Rochester, Minnesota, United States, 2 Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States, 3 Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States

To investigate the utility of MRE-derived mechanical properties in characterizing diseased hepatic tissue, we performed multifrequency 3-D/3-axis MRE on three different mouse models with chronic liver diseases that involved varying degrees of hepatic inflammation, fibrosis, congestion and portal hypertension. Results demonstrated systematic variations in mechanical properties with hepatic inflammation, fibrosis and increased portal pressure. The findings offer preliminary evidence of the potential to extend MRE to distinguish and independently assess necroinflammatory, congestive, and fibrotic processes.

13:42 0372.
Pre- and postprandial arterial and portal venous liver perfusion using selective spin labeling MRI with Look-Locker read-out
Hanke J. Schalkx 1 , Marijn van Stralen 2 , Nicky H.G.M. Peters 1 , Wouter B. Veldhuis 1 , Maarten S Van Leeuwen 1 , Josien P.W. Pluim 2 , Esben T. Petersen 1 , and Maurice A.A.J. van den Bosch 1
1 Radiology, University Medical Center, Utrecht, Netherlands, 2 Image Sciences Institute, University Medical Center, Utrecht, Netherlands

Spin labeling (SL) MRI of the liver has been performed before, but has not been done using Look-Locker readout in humans. We investigated arterial and portal SL-MRI with Look-Locker readout in healthy volunteers to improve quantification by taking regional bolus arrival times into account. Portal venous liver perfusion significantly increased after meal ingestion, while arterial liver perfusion decreased although not significantly. Postprandial portal venous perfusion change based on SL-MRI with LL readout showed fair correlation with portal venous flow changes. SL-MRI is non-invasive and could potentially contribute to diagnosis and treatment monitoring of liver diseases with elimination of contrast-related risks.

13:54 0373. The influence of inflammation and fibrosis on multifrequency and monofrequency MR elastography parameters: a study in 47 patients with chronic viral hepatitis
Philippe Garteiser 1 , Gaspard D'Assignies 1 , Helena S Leito 2 , Feryel Mouri 3 , Valrie Vilgrain 1,4 , Ralph Sinkus 5 , and Bernard E Van Beers 1,4
1 CRB3, INSERM, Paris, 75018, France, 2 Center for Neuroscience and cell Biology, University of Coimbra, Coimbra, Coimbra, Portugal, 3 Hepatology department, Hpital Beaujon, AP-HP, Clichy, France, 4 Radiology department, Hpital Beaujon, AP-HP, Clichy, France, 5 Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

The quantification of liver inflammation has an important clinical impact in chronic liver diseases such as nonalcoholic steatohepatitis and viral hepatitis. Yet, accurate and noninvasive methods for assessing liver inflammation are lacking, and histopathological analysis of liver biopsies remains the gold standard despite its invasiveness and lack of spatial coverage. In this MR elastography study on patients with viral hepatitis, the wave scattering coefficient, a multifrequency mechanical parameter, is found to be mainly determined by inflammation independently from underlying levels of fibrosis. Thus, the measurement of fibrosis and inflammation can reliably be quantified in an independent fashion with MRE.

14:06 0374. Diurnal Variation of Portal Hemodynamics with 4D flow MRI
Alejandro Roldn-Alzate 1 , Camilo A Campo 1 , Kevin M Johnson 2 , Oliver Wieben 1 , and Scott B Reeder 1
1 Radiology, University of Wisconsin, Madison, Wisconsin, United States, 2 Medical Physics, University of Wisconsin, Madison, Wisconsin, United States

The purpose of this study was to evaluate diurnal changes in mesenteric blood flow in normal subjects and patients with portal hypertension using 4D-flow-MRI. Three patients and seven controls were studied. A total of 5 4D-flow-MRI acquisitions were performed along the day to mimic potential imaging schedules. Healthy controls revealed larger changes in blood flow than those in portal hypertension patients. Reduced hemodynamic response in patients may be due to structural and functional vascular changes resulting from cirrhosis. A comprehensive characterization of portal hypertension hemodynamics using 4D-flow MRI would provide valuable information for stratification of variceal bleeding risk in patients.

14:18 0375. Assessment of the pancreatic shear stiffness in healthy volunteers with MR Elastography
Yu Shi 1,2 , Kevin J. Glaser 1 , Jun Chen 1 , and Richard L. Ehman 1
1 Mayo Clinic, Rochester, MN, United States, 2 Department of radiology, Shengjing hospital, Shenyang, Liaoning, China

This study showed that pancreatic MRE using 3D-EPI MRE is feasible in healthy volunteers at low frequencies (40Hz and 60Hz). The shear stiffness for each individual subject and each pancreatic part was consistent among the subjects (approximately 1.0-1.5 kPa at 40 Hz and 1.5-2.5 kPa at 60 Hz). Using 40-Hz vibrations might be more suitable for pancreatic MRE than 60-Hz motion based on the lower CV and higher ICC for inter-rater agreements. For obese subjects, the waves are less likely to penetrate at 60 Hz, causing noise biases and false stiffness estimates.

14:30 0376. Frame-by-Frame 1H MRS for In Vivo Pancreatic Fat Quantification
Qing Yuan 1 , Daniella F Pinho 1 , Ivan E Dimitrov 2,3 , Ivan Pedrosa 1,2 , Yin Xi 1 , Ildiko Lingvay 4 , Anna Vanderheiden 4 , and Robert E Lenkinski 1,2
1 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3 Philips Medical Systems, Cleveland, OH, United States, 4 Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States

Accurate pancreatic fat quantification using 1H MRS in humans is challenging due to the fact that the pancreas is surrounded by visceral fat, and it moves with respiration. In this study, frame-by-frame acquisition with different respiratory compensation methods was performed. Single frame spectrum analysis shows large variation of fat fraction regardless of the respiratory compensation method utilized. Our results indicate that frame-by-frame acquisition is crucial for 1H MRS of pancreas in vivo. Using the minimum fat fraction from all frames may be a more reliable method when measuring pancreatic fat content.

14:42 0377. Assessing Portal Vein Contribution on Hepatic Perfusion based on Arterial Spin Labeling MRI
Xiang He 1 , Serter Gumus 1 , and Kyong Tae Bae 1
1 Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States

Assessment of hemodynamic changes in the liver is particularly challenging due to the dual blood supply. The portal vein and hepatic artery contribution are altered, both globally and regionally, in many liver diseases. In this study, a FAIR-based pulsed ASL approach with cardiac gating was adopted to quantify portal venous fraction in healthy controls. By accounting for the hemodynamic difference of hepatic supplying vessels, the proposed approach can separate the contributions from the portal vein and hepatic artery. This opens new opportunities to detect global and regional alterations in hepatic flow pattern in liver disease patients without contrast agent.

14:54 0378. Intravoxel Incoherent Motion MR Imaging shows lower pure molecular diffusion, lower diffusion fraction linked to microcirculation, and lower perfusion-related diffusion in fibrotic livers with a severity correlated manner
Yi-Xiang Wang 1 , Pu-Xuan Lu 2 , Hua Huang 2 , Feng Zhao 1 , and Jing Yuan 1
1 Dept Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, 2 Department of Radiology, the Shenzhen Third People's Hospital, Shenzhen, Guangdong, China

This current study reports the results of intravoxel incoherent motion (IVIM)-based diffusion weighted imaging evaluation of 17 healthy volunteers and 34 liver fibrosis subjects. Pure molecular diffusion (D), the fraction of the diffusion linked to microcirculation (f), and perfusion-related diffusion (D*) were computed. The results demonstrated all D value, f value, and D* value were significantly lower in the fibrosis livers compared with the healthy livers, and progressively lower as the severity of liver fibrosis increased.

15:06 0379. Shear Wave Speed and Attenuation as Surrogate Imaging Biomarkers for the Quantification of Liver Fibrosis and Inflammation
Ahmed M. Gharib 1 , Simon Lambert 2 , Khaled Z. Abd-Elmoniem 1 , Ahmed A. Harouni 1 , Theo Heller 1 , Caryn Morse 1 , and Ralph Sinkus 3
1 National Institutes of Health, Bethesda, MD, United States, 2 Division of Imaging Sciences and Biomedical Engineering, Kings College, London, England, United Kingdom, 3 Division of Imaging Sciences and Biomedical Engineering, King's College, London, England, United Kingdom

Liver MR-elastography (MRE) was performed at 3T on 17 patients with known biopsy proven chronic liver disease. Shear wave speed and the shear wave attenuation were calculated at 26Hz and 58Hz. Both frequencies demonstrated increase shear wave speed that closely follows an increase in fibrosis. However, at 56Hz the shear wave attenuation strongly increases for fibrosis:inflammation ratio <1. This indicates a potential clinical role for this technique to non-invasively assess fibrosis and inflammation in patients with chronic liver disease at 3T. This might be of clinical value in mentoring disease evolution and/or response to therapy in these patients.

15:18 0380. Measuring dynamic changes in liver perfusion and blood flow following a meal challenge
Eleanor F Cox 1 , Naaventhan Palaniyappan 2 , Guru P Aithal 2 , Indra Neil Guha 2 , and Sue T Francis 1
1 Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom

The dynamic postprandial changes in hepatic blood flow and perfusion to a meal challenge are assessed in healthy subjects using phase contrast MRI and multiphase arterial spin labelling. We show an increase in portal vein flow at 25 min and a reduction in hepatic artery (HA) flow at 50 min, reflecting the HA buffer response (HABR). Perfusion is found to increase considerably following meal ingestion and closely match the HABR response to meal ingestion. This protocol will be applied to assess dynamic alterations in blood flow and perfusion in liver disease where flow, perfusion and vasodilation may be altered.

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