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Abstract #0371

Advanced Assessment of Liver Diseases with Magnetic Resonance Elastography in Mouse Models

Meng Yin 1 , Douglas A. Simonetto 2 , Jason L. Bakeberg 3 , Anuradha Krishnan 2 , Kevin J. Glaser 1 , Vijay H. Shah 2 , Christopher J. Ward 3 , Peter C. Harris 3 , Michael R. Charlton 2 , Armando Manduca 1 , and Richard L. Ehman 1

1 Radiology, Mayo Clinic, Rochester, Minnesota, United States, 2 Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States, 3 Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States

To investigate the utility of MRE-derived mechanical properties in characterizing diseased hepatic tissue, we performed multifrequency 3-D/3-axis MRE on three different mouse models with chronic liver diseases that involved varying degrees of hepatic inflammation, fibrosis, congestion and portal hypertension. Results demonstrated systematic variations in mechanical properties with hepatic inflammation, fibrosis and increased portal pressure. The findings offer preliminary evidence of the potential to extend MRE to distinguish and independently assess necroinflammatory, congestive, and fibrotic processes.

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