Abstract #0373
The influence of inflammation and fibrosis on multifrequency and monofrequency MR elastography parameters: a study in 47 patients with chronic viral hepatitis
Philippe Garteiser 1 , Gaspard D'Assignies 1 , Helena S Leito 2 , Feryel Mouri 3 , Valrie Vilgrain 1,4 , Ralph Sinkus 5 , and Bernard E Van Beers 1,4
1
CRB3, INSERM, Paris, 75018, France,
2
Center
for Neuroscience and cell Biology, University of
Coimbra, Coimbra, Coimbra, Portugal,
3
Hepatology
department, Hpital Beaujon, AP-HP, Clichy, France,
4
Radiology
department, Hpital Beaujon, AP-HP, Clichy, France,
5
Division
of Imaging Sciences and Biomedical Engineering, King's
College London, London, United Kingdom
The quantification of liver inflammation has an
important clinical impact in chronic liver diseases such
as nonalcoholic steatohepatitis and viral hepatitis.
Yet, accurate and noninvasive methods for assessing
liver inflammation are lacking, and histopathological
analysis of liver biopsies remains the gold standard
despite its invasiveness and lack of spatial coverage.
In this MR elastography study on patients with viral
hepatitis, the wave scattering coefficient, a
multifrequency mechanical parameter, is found to be
mainly determined by inflammation independently from
underlying levels of fibrosis. Thus, the measurement of
fibrosis and inflammation can reliably be quantified in
an independent fashion with MRE.
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