Assessing Portal Vein Contribution on Hepatic Perfusion based on Arterial Spin Labeling MRI

Assessment of hemodynamic changes in the liver is particularly challenging due to the dual blood supply. The portal vein and hepatic artery contribution are altered, both globally and regionally, in many liver diseases. In this study, a FAIR-based pulsed ASL approach with cardiac gating was adopted to quantify portal venous fraction in healthy controls. By accounting for the hemodynamic difference of hepatic supplying vessels, the proposed approach can separate the contributions from the portal vein and hepatic artery. This opens new opportunities to detect global and regional alterations in hepatic flow pattern in liver disease patients without contrast agent.

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