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Abstract #0380

Measuring dynamic changes in liver perfusion and blood flow following a meal challenge

Eleanor F Cox 1 , Naaventhan Palaniyappan 2 , Guru P Aithal 2 , Indra Neil Guha 2 , and Sue T Francis 1

1 Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom

The dynamic postprandial changes in hepatic blood flow and perfusion to a meal challenge are assessed in healthy subjects using phase contrast MRI and multiphase arterial spin labelling. We show an increase in portal vein flow at 25 min and a reduction in hepatic artery (HA) flow at 50 min, reflecting the HA buffer response (HABR). Perfusion is found to increase considerably following meal ingestion and closely match the HABR response to meal ingestion. This protocol will be applied to assess dynamic alterations in blood flow and perfusion in liver disease where flow, perfusion and vasodilation may be altered.

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