Abstract #0380
Measuring dynamic changes in liver perfusion and blood flow following a meal challenge
Eleanor F Cox 1 , Naaventhan Palaniyappan 2 , Guru P Aithal 2 , Indra Neil Guha 2 , and Sue T Francis 1
1
Sir Peter Mansfield Magnetic Resonance
Centre, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
2
NIHR
Biomedical Research Unit in Gastrointestinal and Liver
Diseases, Nottingham University Hospitals NHS Trust and
the University of Nottingham, Nottingham, United Kingdom
The dynamic postprandial changes in hepatic blood flow
and perfusion to a meal challenge are assessed in
healthy subjects using phase contrast MRI and multiphase
arterial spin labelling. We show an increase in portal
vein flow at 25 min and a reduction in hepatic artery
(HA) flow at 50 min, reflecting the HA buffer response (HABR).
Perfusion is found to increase considerably following
meal ingestion and closely match the HABR response to
meal ingestion. This protocol will be applied to assess
dynamic alterations in blood flow and perfusion in liver
disease where flow, perfusion and vasodilation may be
altered.
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